Innovation and robustness in complex regulatory gene networks
Summary. This paper examines how evolutionary innovation occurs in gene regulatory networks controlling embryonic development. The researchers show that networks producing the same gene expression patterns form connected networks in genotype space, allowing evolution to explore diverse genetic changes while maintaining viable phenotypes. Robustness to mutations, rather than hindering innovation, actually enables long-term evolutionary innovation by keeping organisms close to functional states.
Cite this article
Ciliberti, S., Martin, O., & Wagner, A.. (2007). Innovation and robustness in complex regulatory gene networks. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.0705396104
Ciliberti, Stefano, et al. “Innovation and robustness in complex regulatory gene networks.” Proceedings of the National Academy of Sciences, 2007. https://doi.org/10.1073/pnas.0705396104.
Ciliberti, Stefano, Olivier Martin, and Andreas Wagner. 2007. “Innovation and robustness in complex regulatory gene networks.” Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.0705396104.
@article{ciliberti-2007-innovation-robustness-complex-regulatory-gene,
title = {Innovation and robustness in complex regulatory gene networks},
author = {Stefano Ciliberti and Olivier Martin and Andreas Wagner},
journal = {Proceedings of the National Academy of Sciences},
year = {2007},
doi = {10.1073/pnas.0705396104},
url = {https://doi.org/10.1073/pnas.0705396104}
}
TY - JOUR TI - Innovation and robustness in complex regulatory gene networks AU - Stefano Ciliberti AU - Olivier Martin AU - Andreas Wagner JO - Proceedings of the National Academy of Sciences PY - 2007 DO - 10.1073/pnas.0705396104 UR - https://doi.org/10.1073/pnas.0705396104 ER -
Details
- DOI
- 10.1073/pnas.0705396104
- Countries
- France, Switzerland
- Regions
- Europe
- Categories
- innovation-theory, general-innovation
- Added
- 2026-04-28