Low Buffer Capacity and Alternating Motility along the Human Gastrointestinal Tract: Implications for <i>in Vivo</i> Dissolution and Absorption of Ionizable Drugs
Summary. This paper is not about rural innovation. It is a pharmaceutical sciences study examining pH, buffer capacity, and motility in the human gastrointestinal tract to improve drug dissolution and absorption predictions. The authors measured these properties in healthy subjects after ibuprofen administration under fasted and fed conditions, finding extremely low buffer capacity throughout the upper GI tract with important implications for oral drug delivery formulation.
Cite this article
Hens, B., Tsume, Y., Bermejo, M., Paixão, P., Koenigsknecht, M. J., Baker, J., Hasler, W. L., Lionberger, R., Fan, J., Dickens, J., Shedden, K., Wen, B., Wysocki, J., Löebenberg, R., Lee, A., Frances, A., Amidon, G., Yu, A., Benninghoff, G., . . . Amidon, G. L.. (2017). Low Buffer Capacity and Alternating Motility along the Human Gastrointestinal Tract: Implications for <i>in Vivo</i> Dissolution and Absorption of Ionizable Drugs. Molecular Pharmaceutics. https://doi.org/10.1021/acs.molpharmaceut.7b00426
Hens, Bart, et al. “Low Buffer Capacity and Alternating Motility along the Human Gastrointestinal Tract: Implications for <i>in Vivo</i> Dissolution and Absorption of Ionizable Drugs.” Molecular Pharmaceutics, 2017. https://doi.org/10.1021/acs.molpharmaceut.7b00426.
Hens, Bart, Yasuhiro Tsume, Marival Bermejo, Paulo Paixão, Mark J. Koenigsknecht, Jason Baker, William L. Hasler, et al.. 2017. “Low Buffer Capacity and Alternating Motility along the Human Gastrointestinal Tract: Implications for <i>in Vivo</i> Dissolution and Absorption of Ionizable Drugs.” Molecular Pharmaceutics. https://doi.org/10.1021/acs.molpharmaceut.7b00426.
@article{hens-2017-low-buffer-capacity-alternating-motility,
title = {Low Buffer Capacity and Alternating Motility along the Human Gastrointestinal Tract: Implications for <i>in Vivo</i> Dissolution and Absorption of Ionizable Drugs},
author = {Bart Hens and Yasuhiro Tsume and Marival Bermejo and Paulo Paixão and Mark J. Koenigsknecht and Jason Baker and William L. Hasler and Robert Lionberger and Jianghong Fan and Joseph Dickens and Kerby Shedden and Bo Wen and Jeffrey Wysocki and Raimar Löebenberg and Allen Lee and Ann Frances and G.E. Amidon and Alex Yu and Gail Benninghoff and Niloufar Salehi and Arjang Talattof and Duxin Sun and Gordon L. Amidon},
journal = {Molecular Pharmaceutics},
year = {2017},
doi = {10.1021/acs.molpharmaceut.7b00426},
url = {https://doi.org/10.1021/acs.molpharmaceut.7b00426}
}
TY - JOUR TI - Low Buffer Capacity and Alternating Motility along the Human Gastrointestinal Tract: Implications for <i>in Vivo</i> Dissolution and Absorption of Ionizable Drugs AU - Bart Hens AU - Yasuhiro Tsume AU - Marival Bermejo AU - Paulo Paixão AU - Mark J. Koenigsknecht AU - Jason Baker AU - William L. Hasler AU - Robert Lionberger AU - Jianghong Fan AU - Joseph Dickens AU - Kerby Shedden AU - Bo Wen AU - Jeffrey Wysocki AU - Raimar Löebenberg AU - Allen Lee AU - Ann Frances AU - G.E. Amidon AU - Alex Yu AU - Gail Benninghoff AU - Niloufar Salehi AU - Arjang Talattof AU - Duxin Sun AU - Gordon L. Amidon JO - Molecular Pharmaceutics PY - 2017 DO - 10.1021/acs.molpharmaceut.7b00426 UR - https://doi.org/10.1021/acs.molpharmaceut.7b00426 ER -
Details
- DOI
- 10.1021/acs.molpharmaceut.7b00426
- Countries
- United States, Spain, Portugal, Canada
- Regions
- North America, Europe
- Categories
- general-innovation
- Added
- 2026-04-28