Widespread contribution of transposable elements to the innovation of gene regulatory networks

Vasavi Sundaram, Yong Cheng, Zhihai Ma, Daofeng Li, Xiaoyun Xing, Peter Edge, M Snyder, Ting Wang · 2014 · Genome Research

Summary. This paper is not about rural innovation. It is a molecular biology study examining how transposable elements contribute to the evolution of gene regulatory networks in mammals. The authors mapped transcription factor binding sites across human and mouse cell lines and found that transposable elements account for approximately 20% of these binding sites, with significant variation across different transcription factors. They conclude that transposable elements have been a major driver of regulatory innovation during mammalian evolution.

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Sundaram, V., Cheng, Y., Ma, Z., Li, D., Xing, X., Edge, P., Snyder, M., & Wang, T.. (2014). Widespread contribution of transposable elements to the innovation of gene regulatory networks. Genome Research. https://doi.org/10.1101/gr.168872.113

@article{sundaram-2014-widespread-contribution-transposable-elements-innovation,
  title   = {Widespread contribution of transposable elements to the innovation of gene regulatory networks},
  author  = {Vasavi Sundaram and Yong Cheng and Zhihai Ma and Daofeng Li and Xiaoyun Xing and Peter Edge and M Snyder and Ting Wang},
  journal = {Genome Research},
  year    = {2014},
  doi     = {10.1101/gr.168872.113},
  url     = {https://doi.org/10.1101/gr.168872.113}
}

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TI  - Widespread contribution of transposable elements to the innovation of gene regulatory networks
AU  - Vasavi Sundaram
AU  - Yong Cheng
AU  - Zhihai Ma
AU  - Daofeng Li
AU  - Xiaoyun Xing
AU  - Peter Edge
AU  - M Snyder
AU  - Ting Wang
JO  - Genome Research
PY  - 2014
DO  - 10.1101/gr.168872.113
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Details

DOI: 10.1101/gr.168872.113
Countries: United States
Regions: North America
Categories: general-innovation
Added: 2026-04-28